Intra-Vital  Microscopy MouseFix

So far, intravital microscopy in the bone marrow is limited to a time frame of a few hours and an imaging depth of 100 -150 μm. Since immune reactions and bone healing processes take days to weeks and highly resolved, functional analysis of the dynamics in skeletal and immune system had not been achieved, we have developed a reproducible longitudinal microendoscopy technique based on gradient index (GRIN) rod lenses.

The newly developed imaging technique, LIMB, enables for the first time longitudinal, dynamic in vivo studies of the osteo-immune system in the murine bone marrow.

IMPLANTS

RIS.401.160
MouseFix IVM Plate combined

RIS.401.161
MouseFix IVM Referenze Plate thread combined

RIS.401.162/164
MouseFix IVM endosope tube (excl. GRIN Needle Microendoscope)

RIS.401.100
MouseFix screw, L=2.00 mm

INSTRUMENTS
IVM table & specimen holder
This article needs to be customized to the laser scanning microscope

CONSUMABLES

RIS.592.200
Drill bit 0.30 mm

RIS.592.210
Drill bit 0.31 mm

RIS.590.111
Square box wrench 0.50 mm